有机立体化学-Slid-8

新型螺环双膦配体

OHOH2 (50 atm) / Ru /L*Pht-BuOK / 2-PropanolPh*Ligand S/C Conv (%) ee (%)________________________________PAr2 SDP 5000 100 90PAr2Tol-SDP 5000 99 89An-SDP 5000 100 92Xyl-SDP 5000 100 99Xyl-SDP 10,000 100 99 SDPXyl-SDP 100,000 98 98

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ClOHBrOHBrOHF3COHH3COH98% ee99% ee99% ee99% eeOHOHOHOHClBrH3CO98% ee99% ee99% ee99.5% eeOHOHFeOHOHOS99.2% ee98% ee98% ee98% ee99.2% eeOH98% eeOH96% ee55