loadingLivin和Smac在膀胱移行细胞癌中的表达及相关性研究
李清林;蒋雷鸣;伍运筹;曾宪华;石海林;侯巧燕
【期刊名称】《天津医药》 【年(卷),期】2012(040)004
【摘要】Objective: To investigate the expression of Livin protein and second mitochondria-derived activator of cas-pases (Smac) protein in the bladder transitional cell carcinoma (BTCC), and their correlation thereof. Methods:The expression levels of Livin and Smac proteins were assessed in 42 (issue samples of BTCC and 18 samples of adjacent normal mucosa by SABC immunohistochemistry, and their relationships with clinical pathological features were analyzed. Results: The positive expression rates of Livin and Smac proteins in BTCC were 73.8% (31/42) and 28.6% (12/42), while they were 0 and 77.8% (14/18) in 18 samples of adjacent normal mucosa. The differences in expressions of Livin and Smac proteins were significant between BTCC and adjacent normal mucosa (P < 0.01). There were significant differences in expressions of Livin and Smac proteins between patients with and without recurrence (P < 0.05). There were no significant differences between gender, age, hislological grades, clinical stages, the number of tumors and expressions of Livin and Smac proteins in BTCC. There was a negative correlation between the expression levels of Livin proteins and Smac proteins in BTCC (r.= -0.462, P < 0.05). Conclusion: The relatively higher